TY - JOUR AU - Arikan, Sanem AU - Demirel, Kerime PY - 2022/12/07 Y2 - 2024/03/28 TI - Investigation of the Relationship between IL-6, IL-6R and CXCL5 Polymorphisms and Obesity in Denizli Province of Turkey JF - Genetics & Applications JA - GenApp VL - 6 IS - 2 SE - Research Articles DO - 10.31383/ga.vol6iss2ga04 UR - https://genapp.ba/editions/index.php/journal/article/view/150 SP - 41-50 AB - <p>Obesity and its effects on increasing morbidity and mortality have reached the level of an epidemic with a high frequency in modern populations. <em>IL-6</em> released from adipose tissue is known to trigger the chronic inflammation in obesity. <em>CXCL5</em>, which mediates the activation and migration of neutrophils, has been found at high levels in obese subjects. In our study, we aimed to investigate the possible effects of <em>IL-6</em>, <em>IL-6R</em> and <em>CXCL5</em>, polymorphisms and haplotypes on the development of obesity. We studied <em>IL-6</em>, rs2069827   (-1363, G/T), rs1800797 (-597, G/A), rs1800796 (-572, G/C) and rs1800795 (-174, G/C), <em>IL-6R</em> rs4845617 (-183, G/A), rs2228145 (+48892, A/C) and <em>CXCL5</em> rs352046 (-156, G/C) polymorphic sites in 60 obesity patients and 59 healthy controls. For genotyping we used PCR-RFLP based approach. The <em>IL-6 </em>rs1800796, rs1800795 and <em>IL-6R</em> rs4845617 G allelles could be the possible genetic factors responsible for obesity. We found similar results in female obese group. The results indicated that there was no association between obesity and other SNPs (rs2069827, rs1800797, and rs1800795 and rs2228145) and <em>CXCL5</em>, rs352046. The results of <em>IL-6</em> and <em>IL-6R</em> haplotype analysis by global differentiation test showed that haplotypes may have different distributions between obese and controls. Our results showed that polymorphisms and possible haplotypes in <em>IL-6</em> and <em>IL-6R</em> genes, which have an important role in inflammation, may affect the development of obesity. This study points out the necessity of investigating the possible effects of gene polymorphisms of other cytokines and their receptors in the development of obesity in larger populations.</p> ER -